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Survival analysis: showing that the hazard rate function is approximately the probability of dying


Finding Survival Function given hazard rateExpected Residual lifetimeCalculating the probability of something given the hazard rate function?Find the constants for the independence of a random variableProbability: Hazard Rate functionprobability, hazard rateFind the relationship between $S_0(phi x)$ with $S_1(x)$The Hazard Function: derivation and assumptions of random variableIs the Conditional Expectation of an SDE the SDE of a Conditional Expectation?Survival function and existence of moments given parameter range













1












$begingroup$


If you're comfortable with survival analysis, please feel free to skip to the Question section. Otherwise, I set up notation for my question here.



Setup



Let $L$ be a nonnegative continuous random variable such that



$$
mathbbPL geq t = e^-H(t) = e^- int_0^t h(s) ds
$$



where $H(t)$ is the hazard function and $h(t)$ is the hazard rate function. I want to show that



$$
h(t) u approx mathbbPL < t + u mid L geq t
$$



In words, the probability that you do not survive longer than $u$ given that you have already survived for $t$ is proportional to an infinitesimal slice of area under $h(t)$ or roughly the height of $h(t)$.



Consider this derivation:



$$
beginalign
mathbbPL geq t + u mid L geq t
&= fracmathbbPL geq t + u, L geq tmathbbPL geq t
\\
&stackreltextind= fracmathbbPL geq t + umathbbPL geq t
\\
&= frace^-H(t+u)e^- H(t)
\\
&= frace^-int_0^t+u h(s)dse^-int_0^t h(s)ds
\\
&= e^-int_0^t+u h(s)ds + int_0^t h(s)ds
\\
&= e^- int_t^t+u h(s)ds
endalign
$$



So the probability of not surviving in $u$ years if you have lived $t$ years is given by



$$
mathbbPL < t + u mid L geq t = 1 - mathbbPL geq t + u mid L geq t = 1 - e^- int_t^t+u h(s)ds
$$



Now let $F_t(u) = 1 - e^- int_t^t+u h(s) ds$. Therefore,



$$
beginalign
mathbbPL < t + u mid L geq t &= F_t(u)
\\
lim_u rightarrow 0 mathbbPL < t + u mid Lgeq t &= lim_u rightarrow 0 F_t(u)
\\
lim_u rightarrow 0 fracmathbbPL < t + u mid L geq tu &= lim_u rightarrow 0 fracF_t(u)u
\\
lim_u rightarrow 0 fracmathbbPL < t + u mid L geq tu &= lim_u rightarrow 0 fracF_t(u) - F_t(0)u
endalign
$$



where the last step holds because $F_t(0) = 1 - e^0 = 0$.



Question



Here is what I don't understand. The next step in the course notes is



$$
lim_u rightarrow 0 fracF_t(u) - F_t(0)u = fracpartialpartial u F_t(u) Bigg|_u=0 = h(t) tag$star$
$$



But I am used to the definition of a derivative as being



$$
lim_h rightarrow 0 fracf(x+h) - f(x)h = fracpartialpartial x f(x)
$$



and I am unable to see why $star$ holds.










share|cite|improve this question











$endgroup$
















    1












    $begingroup$


    If you're comfortable with survival analysis, please feel free to skip to the Question section. Otherwise, I set up notation for my question here.



    Setup



    Let $L$ be a nonnegative continuous random variable such that



    $$
    mathbbPL geq t = e^-H(t) = e^- int_0^t h(s) ds
    $$



    where $H(t)$ is the hazard function and $h(t)$ is the hazard rate function. I want to show that



    $$
    h(t) u approx mathbbPL < t + u mid L geq t
    $$



    In words, the probability that you do not survive longer than $u$ given that you have already survived for $t$ is proportional to an infinitesimal slice of area under $h(t)$ or roughly the height of $h(t)$.



    Consider this derivation:



    $$
    beginalign
    mathbbPL geq t + u mid L geq t
    &= fracmathbbPL geq t + u, L geq tmathbbPL geq t
    \\
    &stackreltextind= fracmathbbPL geq t + umathbbPL geq t
    \\
    &= frace^-H(t+u)e^- H(t)
    \\
    &= frace^-int_0^t+u h(s)dse^-int_0^t h(s)ds
    \\
    &= e^-int_0^t+u h(s)ds + int_0^t h(s)ds
    \\
    &= e^- int_t^t+u h(s)ds
    endalign
    $$



    So the probability of not surviving in $u$ years if you have lived $t$ years is given by



    $$
    mathbbPL < t + u mid L geq t = 1 - mathbbPL geq t + u mid L geq t = 1 - e^- int_t^t+u h(s)ds
    $$



    Now let $F_t(u) = 1 - e^- int_t^t+u h(s) ds$. Therefore,



    $$
    beginalign
    mathbbPL < t + u mid L geq t &= F_t(u)
    \\
    lim_u rightarrow 0 mathbbPL < t + u mid Lgeq t &= lim_u rightarrow 0 F_t(u)
    \\
    lim_u rightarrow 0 fracmathbbPL < t + u mid L geq tu &= lim_u rightarrow 0 fracF_t(u)u
    \\
    lim_u rightarrow 0 fracmathbbPL < t + u mid L geq tu &= lim_u rightarrow 0 fracF_t(u) - F_t(0)u
    endalign
    $$



    where the last step holds because $F_t(0) = 1 - e^0 = 0$.



    Question



    Here is what I don't understand. The next step in the course notes is



    $$
    lim_u rightarrow 0 fracF_t(u) - F_t(0)u = fracpartialpartial u F_t(u) Bigg|_u=0 = h(t) tag$star$
    $$



    But I am used to the definition of a derivative as being



    $$
    lim_h rightarrow 0 fracf(x+h) - f(x)h = fracpartialpartial x f(x)
    $$



    and I am unable to see why $star$ holds.










    share|cite|improve this question











    $endgroup$














      1












      1








      1





      $begingroup$


      If you're comfortable with survival analysis, please feel free to skip to the Question section. Otherwise, I set up notation for my question here.



      Setup



      Let $L$ be a nonnegative continuous random variable such that



      $$
      mathbbPL geq t = e^-H(t) = e^- int_0^t h(s) ds
      $$



      where $H(t)$ is the hazard function and $h(t)$ is the hazard rate function. I want to show that



      $$
      h(t) u approx mathbbPL < t + u mid L geq t
      $$



      In words, the probability that you do not survive longer than $u$ given that you have already survived for $t$ is proportional to an infinitesimal slice of area under $h(t)$ or roughly the height of $h(t)$.



      Consider this derivation:



      $$
      beginalign
      mathbbPL geq t + u mid L geq t
      &= fracmathbbPL geq t + u, L geq tmathbbPL geq t
      \\
      &stackreltextind= fracmathbbPL geq t + umathbbPL geq t
      \\
      &= frace^-H(t+u)e^- H(t)
      \\
      &= frace^-int_0^t+u h(s)dse^-int_0^t h(s)ds
      \\
      &= e^-int_0^t+u h(s)ds + int_0^t h(s)ds
      \\
      &= e^- int_t^t+u h(s)ds
      endalign
      $$



      So the probability of not surviving in $u$ years if you have lived $t$ years is given by



      $$
      mathbbPL < t + u mid L geq t = 1 - mathbbPL geq t + u mid L geq t = 1 - e^- int_t^t+u h(s)ds
      $$



      Now let $F_t(u) = 1 - e^- int_t^t+u h(s) ds$. Therefore,



      $$
      beginalign
      mathbbPL < t + u mid L geq t &= F_t(u)
      \\
      lim_u rightarrow 0 mathbbPL < t + u mid Lgeq t &= lim_u rightarrow 0 F_t(u)
      \\
      lim_u rightarrow 0 fracmathbbPL < t + u mid L geq tu &= lim_u rightarrow 0 fracF_t(u)u
      \\
      lim_u rightarrow 0 fracmathbbPL < t + u mid L geq tu &= lim_u rightarrow 0 fracF_t(u) - F_t(0)u
      endalign
      $$



      where the last step holds because $F_t(0) = 1 - e^0 = 0$.



      Question



      Here is what I don't understand. The next step in the course notes is



      $$
      lim_u rightarrow 0 fracF_t(u) - F_t(0)u = fracpartialpartial u F_t(u) Bigg|_u=0 = h(t) tag$star$
      $$



      But I am used to the definition of a derivative as being



      $$
      lim_h rightarrow 0 fracf(x+h) - f(x)h = fracpartialpartial x f(x)
      $$



      and I am unable to see why $star$ holds.










      share|cite|improve this question











      $endgroup$




      If you're comfortable with survival analysis, please feel free to skip to the Question section. Otherwise, I set up notation for my question here.



      Setup



      Let $L$ be a nonnegative continuous random variable such that



      $$
      mathbbPL geq t = e^-H(t) = e^- int_0^t h(s) ds
      $$



      where $H(t)$ is the hazard function and $h(t)$ is the hazard rate function. I want to show that



      $$
      h(t) u approx mathbbPL < t + u mid L geq t
      $$



      In words, the probability that you do not survive longer than $u$ given that you have already survived for $t$ is proportional to an infinitesimal slice of area under $h(t)$ or roughly the height of $h(t)$.



      Consider this derivation:



      $$
      beginalign
      mathbbPL geq t + u mid L geq t
      &= fracmathbbPL geq t + u, L geq tmathbbPL geq t
      \\
      &stackreltextind= fracmathbbPL geq t + umathbbPL geq t
      \\
      &= frace^-H(t+u)e^- H(t)
      \\
      &= frace^-int_0^t+u h(s)dse^-int_0^t h(s)ds
      \\
      &= e^-int_0^t+u h(s)ds + int_0^t h(s)ds
      \\
      &= e^- int_t^t+u h(s)ds
      endalign
      $$



      So the probability of not surviving in $u$ years if you have lived $t$ years is given by



      $$
      mathbbPL < t + u mid L geq t = 1 - mathbbPL geq t + u mid L geq t = 1 - e^- int_t^t+u h(s)ds
      $$



      Now let $F_t(u) = 1 - e^- int_t^t+u h(s) ds$. Therefore,



      $$
      beginalign
      mathbbPL < t + u mid L geq t &= F_t(u)
      \\
      lim_u rightarrow 0 mathbbPL < t + u mid Lgeq t &= lim_u rightarrow 0 F_t(u)
      \\
      lim_u rightarrow 0 fracmathbbPL < t + u mid L geq tu &= lim_u rightarrow 0 fracF_t(u)u
      \\
      lim_u rightarrow 0 fracmathbbPL < t + u mid L geq tu &= lim_u rightarrow 0 fracF_t(u) - F_t(0)u
      endalign
      $$



      where the last step holds because $F_t(0) = 1 - e^0 = 0$.



      Question



      Here is what I don't understand. The next step in the course notes is



      $$
      lim_u rightarrow 0 fracF_t(u) - F_t(0)u = fracpartialpartial u F_t(u) Bigg|_u=0 = h(t) tag$star$
      $$



      But I am used to the definition of a derivative as being



      $$
      lim_h rightarrow 0 fracf(x+h) - f(x)h = fracpartialpartial x f(x)
      $$



      and I am unable to see why $star$ holds.







      probability statistics






      share|cite|improve this question















      share|cite|improve this question













      share|cite|improve this question




      share|cite|improve this question








      edited Mar 23 at 10:24









      Saad

      20.4k92452




      20.4k92452










      asked Mar 22 at 15:48









      gwggwg

      1,04111023




      1,04111023




















          1 Answer
          1






          active

          oldest

          votes


















          1












          $begingroup$

          If you have a function of two variables $F(t,u)$ (written $F_t(u)$ for your example), then the partial derivative with respect to $u$ is defined by $$fracpartialpartial uF(t,u) =limlimits_sto 0fracF(t, u+s)-F(t,u)s.$$
          To evaluate this at $u=0$, we put $u=0$ on the right-hand side, so
          $$fracpartialpartial uF(t,u)Bigg|_u=0=limlimits_sto 0fracF(t, s)-F(t,0)s.$$
          Writing it with the subscript $t$ notation used in your example (so $F(t,s)=F_t(s)$ and $F(t,0) = F_t(0)$), we see that we have
          $$fracpartialpartial uF_t(u)Bigg|_u=0 =limlimits_s to 0fracF_t(s)-F_t(0)s.$$
          You can now change the $s$ to $u$ if you want, it is just a dummy variable for the limit. This matches the equation your notes had. (If you want to see why this equals $h(t)$, you will need to differentiate $F_t(u) = 1-e^-int_t^t+uh(s), ds$ with respect to $u$ (using the chain rule and Fundamental Theorem of Calculus), and then substitute in $u=0$.)






          share|cite|improve this answer











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            $begingroup$

            If you have a function of two variables $F(t,u)$ (written $F_t(u)$ for your example), then the partial derivative with respect to $u$ is defined by $$fracpartialpartial uF(t,u) =limlimits_sto 0fracF(t, u+s)-F(t,u)s.$$
            To evaluate this at $u=0$, we put $u=0$ on the right-hand side, so
            $$fracpartialpartial uF(t,u)Bigg|_u=0=limlimits_sto 0fracF(t, s)-F(t,0)s.$$
            Writing it with the subscript $t$ notation used in your example (so $F(t,s)=F_t(s)$ and $F(t,0) = F_t(0)$), we see that we have
            $$fracpartialpartial uF_t(u)Bigg|_u=0 =limlimits_s to 0fracF_t(s)-F_t(0)s.$$
            You can now change the $s$ to $u$ if you want, it is just a dummy variable for the limit. This matches the equation your notes had. (If you want to see why this equals $h(t)$, you will need to differentiate $F_t(u) = 1-e^-int_t^t+uh(s), ds$ with respect to $u$ (using the chain rule and Fundamental Theorem of Calculus), and then substitute in $u=0$.)






            share|cite|improve this answer











            $endgroup$

















              1












              $begingroup$

              If you have a function of two variables $F(t,u)$ (written $F_t(u)$ for your example), then the partial derivative with respect to $u$ is defined by $$fracpartialpartial uF(t,u) =limlimits_sto 0fracF(t, u+s)-F(t,u)s.$$
              To evaluate this at $u=0$, we put $u=0$ on the right-hand side, so
              $$fracpartialpartial uF(t,u)Bigg|_u=0=limlimits_sto 0fracF(t, s)-F(t,0)s.$$
              Writing it with the subscript $t$ notation used in your example (so $F(t,s)=F_t(s)$ and $F(t,0) = F_t(0)$), we see that we have
              $$fracpartialpartial uF_t(u)Bigg|_u=0 =limlimits_s to 0fracF_t(s)-F_t(0)s.$$
              You can now change the $s$ to $u$ if you want, it is just a dummy variable for the limit. This matches the equation your notes had. (If you want to see why this equals $h(t)$, you will need to differentiate $F_t(u) = 1-e^-int_t^t+uh(s), ds$ with respect to $u$ (using the chain rule and Fundamental Theorem of Calculus), and then substitute in $u=0$.)






              share|cite|improve this answer











              $endgroup$















                1












                1








                1





                $begingroup$

                If you have a function of two variables $F(t,u)$ (written $F_t(u)$ for your example), then the partial derivative with respect to $u$ is defined by $$fracpartialpartial uF(t,u) =limlimits_sto 0fracF(t, u+s)-F(t,u)s.$$
                To evaluate this at $u=0$, we put $u=0$ on the right-hand side, so
                $$fracpartialpartial uF(t,u)Bigg|_u=0=limlimits_sto 0fracF(t, s)-F(t,0)s.$$
                Writing it with the subscript $t$ notation used in your example (so $F(t,s)=F_t(s)$ and $F(t,0) = F_t(0)$), we see that we have
                $$fracpartialpartial uF_t(u)Bigg|_u=0 =limlimits_s to 0fracF_t(s)-F_t(0)s.$$
                You can now change the $s$ to $u$ if you want, it is just a dummy variable for the limit. This matches the equation your notes had. (If you want to see why this equals $h(t)$, you will need to differentiate $F_t(u) = 1-e^-int_t^t+uh(s), ds$ with respect to $u$ (using the chain rule and Fundamental Theorem of Calculus), and then substitute in $u=0$.)






                share|cite|improve this answer











                $endgroup$



                If you have a function of two variables $F(t,u)$ (written $F_t(u)$ for your example), then the partial derivative with respect to $u$ is defined by $$fracpartialpartial uF(t,u) =limlimits_sto 0fracF(t, u+s)-F(t,u)s.$$
                To evaluate this at $u=0$, we put $u=0$ on the right-hand side, so
                $$fracpartialpartial uF(t,u)Bigg|_u=0=limlimits_sto 0fracF(t, s)-F(t,0)s.$$
                Writing it with the subscript $t$ notation used in your example (so $F(t,s)=F_t(s)$ and $F(t,0) = F_t(0)$), we see that we have
                $$fracpartialpartial uF_t(u)Bigg|_u=0 =limlimits_s to 0fracF_t(s)-F_t(0)s.$$
                You can now change the $s$ to $u$ if you want, it is just a dummy variable for the limit. This matches the equation your notes had. (If you want to see why this equals $h(t)$, you will need to differentiate $F_t(u) = 1-e^-int_t^t+uh(s), ds$ with respect to $u$ (using the chain rule and Fundamental Theorem of Calculus), and then substitute in $u=0$.)







                share|cite|improve this answer














                share|cite|improve this answer



                share|cite|improve this answer








                edited Mar 23 at 10:56

























                answered Mar 23 at 10:39









                Minus One-TwelfthMinus One-Twelfth

                3,343413




                3,343413



























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