Intergenic lcrF RNA thermometer References Navigation menuRF02704004597500092660005836PDBeLcrF"Concerted actions of a thermo-labile regulator and a unique intergenic RNA thermosensor control Yersinia virulence"10.1371/journal.ppat.10025181553-7374328098722359501"Yersinia Type III Secretion System Master Regulator LcrF"10.1128/JB.00686-151098-5530475181326644429expanding ite
Non-coding RNACis-regulatory RNA elementsGene stubs
RNA thermometers5'UTRintergenicLcrF
| LcrF intergenic thermometer | |
|---|---|
 Predicted secondary structure and sequence conservation of LcrF intergenic thermometer | |
| Identifiers | |
| Rfam | RF02704 |
| Other data | |
| Domain(s) | Bacteria |
| GO | 0045975,0009266 |
| SO | 0005836 |
PDB structures | PDBe |
RNA thermometers regulate gene expression in response to temperature allowing pathogens like Yersinia to switch on silent genes after entering the host organism. Usually, RNA thermometers are located in the 5'UTR, but an intergenic RNA thermometer was found in Yersinia pseudotuberculosis. The LcrF RNA thermometer together with the termo-labile YmoA protein activates synthesis of the most crucial virulence activator LcrF (VirF). The RNA thermosensor sequence is 100% identical in all human pathogenic Yersinia species.[1][2]
References
^ Böhme, Katja; Steinmann, Rebekka; Kortmann, Jens; Seekircher, Stephanie; Heroven, Ann Kathrin; Berger, Evelin; Pisano, Fabio; Thiermann, Tanja; Wolf-Watz, Hans (2012-02-01). "Concerted actions of a thermo-labile regulator and a unique intergenic RNA thermosensor control Yersinia virulence". PLOS Pathogens. 8 (2): e1002518. doi:10.1371/journal.ppat.1002518. ISSN 1553-7374. PMC 3280987. PMID 22359501..mw-parser-output cite.citationfont-style:inherit.mw-parser-output .citation qquotes:"""""""'""'".mw-parser-output .citation .cs1-lock-free abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .citation .cs1-lock-subscription abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registrationcolor:#555.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration spanborder-bottom:1px dotted;cursor:help.mw-parser-output .cs1-ws-icon abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Wikisource-logo.svg/12px-Wikisource-logo.svg.png")no-repeat;background-position:right .1em center.mw-parser-output code.cs1-codecolor:inherit;background:inherit;border:inherit;padding:inherit.mw-parser-output .cs1-hidden-errordisplay:none;font-size:100%.mw-parser-output .cs1-visible-errorfont-size:100%.mw-parser-output .cs1-maintdisplay:none;color:#33aa33;margin-left:0.3em.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-formatfont-size:95%.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-leftpadding-left:0.2em.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-rightpadding-right:0.2em
^ Schwiesow, Leah; Lam, Hanh; Dersch, Petra; Auerbuch, Victoria (2015-12-07). "Yersinia Type III Secretion System Master Regulator LcrF". Journal of Bacteriology. 198 (4): 604–614. doi:10.1128/JB.00686-15. ISSN 1098-5530. PMC 4751813. PMID 26644429.
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